Download Aids-Associated Viral Oncogenesis by Charles Wood Ph.D. (auth.), C. Meyers (eds.) PDF

By Charles Wood Ph.D. (auth.), C. Meyers (eds.)

AIDS-associated viral oncology is an important healthcare challenge. because the id of human immunodeficiency virus (HIV)-associated obtained immune illness syndrome (AIDS), the function of viruses in human cancers has develop into acutely obvious over the last two decades. the certainty and therapy of AIDS-associated cancers has develop into a massive challenge between healthcare corporations. Human cancers that have been as soon as infrequent within the inhabitants have now turn into universal in the HIV contaminated inhabitants.

Experts percentage their collective wisdom and think about the scientific and organic features, together with viruses good proven of their roles, in addition to rising new viruses. This quantity might be a source for either participants of the medical and healthcare group and lively researchers during this field.

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"Human immunodeficiency virus (HIV) - linked bought immune ailment syndrome (AIDS) areas members at elevated chance for virally mediated cancers. this article addresses the scientific and organic facets of this subject. exclusive investigators within the box current a accomplished evaluate with relevance to laboratory scientists and working towards clinicians."

Steven T. Rosen, M.D.

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271 TREATMENT OF PEL Simonelli and colleagues,272 in a retrospective study with 277 patients with HIV infection and systemic lymphoma, had 11 individuals in the group that were classified in the PEL category. Eight of the 11 patients received CHOP-like regimen and CR was reached in 42% of the patients, with a median survival of 6 months. One of the three patients receiving no cytotoxic therapy also had CR, which may have occurred as result of HAART. Only two patients survived beyond a year, and both had a CR after cytotoxic therapy or occurring along with antiretroviral therapy.

CR was seen in 81% of patients, and 56% of patients were alive and disease-free at median follow-up of 17 months. AIDS-RELATED LEIOMYOSARCOMA The range of AIDS-associated pediatric cancers resembles that seen in HIVinfected adults, with the addition of leiomyosarcoma. Leiomyosarcoma, a tumor of smooth muscle origin, is a rare tumor in childhood, occurring in the general population at a rate of one case per one million children. 6–8 Jenson and colleagues8 reported several EBV antigens, including latent antigen EBNA-1, expressed from cells cultured from leiomyosarcoma.

AIDS-RELATED PRIMARY CNS LYMPHOMA PCNSL is a rare type of NHL, accounting for 1–2% of all NHLs and <5% of all primary brain tumors. 5 Macmahon and colleagues14 described that EBV genes important for oncogenesis are abundant in patients with PCNSL, suggesting a pathogenic role of EBV in this setting. 15–17 2. AIDS Malignancies 23 ROLE OF EBV IN DIAGNOSIS OF PCNSL EBV studies have been largely used as one of the least invasive ways to diagnose AIDS PCNSL. Specifically, using polymerase chain reaction (PCR) to detect EBV DNA in the CSF is useful for diagnosing AIDS-associated CNS lymphoma.

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