Download Antimalarial Chemotherapy: Mechanisms of Action, Resistance, by Philip J. Rosenthal PDF

By Philip J. Rosenthal

Philip Rosenthal, MD, and a panel of top malaria specialists drawn from academia, the army, and foreign future health corporations survey the most recent clinical knowing of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the outline of vital new pursuits. Their survey covers the present prestige of malarial and antimalarial chemotherapy, the suitable biology and biochemistry of malaria parasites, the antimalarial medicines presently to be had, new chemical ways to chemotherapy, and attainable new goals for chemotherapy. complete and state of the art, Antimalarial Chemotherapy: Mechanisms of motion, Resistance, and New instructions in Drug Discovery in actual fact delineates the entire easy and scientific study now addressing one of many world's significant unresolved illness difficulties, paintings that's now powerfully riding the swift velocity of antimalarial drug discovery this day.

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Additional resources for Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery (Infectious Disease)

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In studies with the inhibitor of TVM development, PPMP, there was a close correlation between the degree of TVM inhibition and the reduction in artemisinin accumulation, strongly suggesting that the TVM accounts for 70% of dihydroartemis- Transport and Trafficking in Plasmodium-Infected Red Cells 33 inin transport in infected red cells (5). This uptake is saturable and temperature dependent, suggesting that it is a carrier-mediated process with a Km of 276 ± 34. 13 nmol/min/106 parasites). Thus, PPMP does not alter the initial interaction of dihydroartemisinin with its carrier and, hence, the carrier must reside at the infected red cell surface rather than within the TVM.

Proc Natl Acad Sci USA 1994;91:509–513. Transport and Trafficking in Plasmodium-Infected Red Cells 39 18. Haldar K. Intracellular trafficking in Plasmodium-infected erythrocytes. Curr Opin Microbiol 1998;1:466–471. 19. Elmendorf HG, Haldar K. Plasmodium falciparum exports the Golgi marker sphingomyelin synthase into a tubovesicular network in the cytoplasm of mature erythrocytes. J Cell Biol 1994;124:449–462. 20. Elmendorf HG, Haldar K. Secretory activities in Plasmodium. Parasitol Today 1993;9:98–102.

41. Buffet PA, Gamain B, Scheidig C, Batuch D, Smith JD, Hernandez-Rivas R, Pouvelle B, Oishi S, Fuji N, Fusai T, Parzy D, Miller LH, Gysin J, Scherf A. Plasmodium falciparum domain mediating adhesion to chondroitin sulfate A: A receptor for human placental infection. Proc Natl Acad Sci USA 1999;96:12,743–12,748. 42. Rowe JA, Moulds JM, Newbold CI, Miller LH. P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor. Nature 1997;388: 292–295. 43.

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