By Albert Segaloff (auth.), William L. McGuire M.D. (eds.)
Breast melanoma is still the focal point of severe easy and scientific learn. In Valurne 1 of this sequence we dealt solely with issues inquisitive about remedy. within the current Valurne 2, we flip our recognition to the experimental biology that is the root for our comprehend ing of difficulties considering breast melanoma etiology, mechanisms of hormone motion, telephone kinetics, experimental chemotherapy, and markers of tumor burden. The individuals to the amount are all famous students who're in my opinion investigating those difficulties. the 1st bankruptcy addresses the query, do hormones reason breast melanoma? Segaloff offers us with a rational up to date evaluation of the present facts. He concludes that hormones via themselves aren't tumor initiators yet particularly adjust the hast setting in order that different cancer agents are powerful. lt is mentioned that the choice of the modeltest method is necessary; you may nearly guarantee any wanted outcome via picking out an ap propriately biased try method. The query of the position of viruses within the etiology of human breast melanoma is still unanswered regardless of stylish stories in mause systems.
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Additional info for Breast Cancer:Advances in Research and Treatment, Vol. 2: Experimental Biology
L. Wynder, Effect of high fat diet on serum prolactin Ievels and mammary cancer development in ovariectomized rats, 68th Annual Meeting of the American Association of Cancer Research, May (1977) (abstract #753). 2 Viruses and Mammary Carcinoma JEFFREY SCHLOM, DAVID COLCHER, WILLIAM DROHAN, DONALD KUFE, AND YOSHIO A. TERAMOTO 1. Introduction Viruses have long been known tobe involved in the etiology of a variety of neoplasms of animals ranging from fowl to nonhuman primates. This involvement has been demonstrated by the isolation of these agents from spontaneaus tumors, their inoculation into animals of the same species, and the reisolation of the particular virus from the subsequent tumor that developed.
The authors do suggest that the functional tumor produces much more prolactin. Bulbrook et al. <56 > conclude from their own studies, and those in the literature, that prolactin is important, not in the etiology of human breast cancer, but only in very specialized animal models. They believe that the similar protective effects of early pregnancy and early castration in humans indicate that large amounts of estrogen given early are protective, and that women who undergo early oophorectomy probably had hyperestrogenism previously.
Geschicter, Diseases of the Breast, J. B. Lippincott, Philadelphia (1943). 21. R. L. Noble, C. S. McEuen, and J. B. Collip, Mammary tumours produced in rats by the action of oestrone tablets, Can. Med. Assoc. ]. 42, 413-417 (1940). 22. R. L. Noble, A new approach to the hormonal cause and control of experimental carcinomas including those of the breast, Ann. R. Coll. Physicians Surg. Can. 9, 169-180 (1976). 23. A. Segaloff and H. Pettigrew, Effect of radiation dosage on the synergism between radiation and estrogen in the production of mammary cancer in the rat Cancer Res.