Download Combating the Threat of Pandemic Influenza: Drug Discovery by Paul F. Torrence PDF

By Paul F. Torrence

Drug discovery for influenza antivirals

Priorities for scuffling with pandemic influenza comprise fast detection and identity, the short management of accessible medicines to regard the an infection, the advance of recent antivirals, and the advance of vaccines. considering that lead-time might be required to supply a good vaccine, antivirals might function a key first defensive position in containing an endemic. varied antivirals, performing via various mechanisms, might support remain the advance of resistant viruses. hence, drug discovery for influenza antivirals is a crucial public health-related endeavor.

With chapters contributed via major foreign experts, this consultant will get readers on top of things at the most modern advances and applied sciences in assorted techniques to drug discovery, covering:
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latest antivirals, together with commonly potent anti-respiratory virus agents
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the improvement of high-throughput screening assays
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IFN resistance
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the advance of nucleic acid-based antiviral drugs
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Antiviral RNAi concepts concentrating on influenza virus
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different promising antiviral drug discovery strategies

struggling with the specter of Pandemic Influenza: Drug Discovery methods consolidates the most recent info on different ways into one accomplished source. it's a useful, hands-on reference for researchers in medicinal chemistry, pharmaceutical chemistry, drug discovery, biochemistry, virology, microbiology, and public health.Content:
Chapter 1 latest Influenza Antivirals: Their Mechanisms of motion and strength within the Face of Avian Influenza (pages 1–37): Erik De Clercq
Chapter 2 improvement of High?Throughput Screening Assays for Influenza (pages 38–72): Diana L. Noah, E. Lucile White and James W. Noah
Chapter three Mechanisms of IFN Resistance through Influenza Virus (pages 73–97): Heather J. Ezelle and Bret A. Hassel
Chapter four widely powerful Anti?Respiratory Virus brokers (pages 98–125): Shiro Shigeta
Chapter five present prestige on improvement of Nucleic Acid?Based Antiviral medicines opposed to Influenza Virus an infection (pages 126–147): Jonathan P. Wong, Mary E. Christopher, Murray Cairns, L.?Q. sunlight, Roderic M. ok. Dale and Andres M. Salazar
Chapter 6 Antiviral RNA Interference techniques concentrating on Influenza Virus and different breathing Viruses (pages 148–165): Joost Haasnoot and Ben Berkhout
Chapter 7 Promising Antiviral Glyco?Molecules from an fit for human consumption Alga (pages 166–182): Toshimitsu Hayashi, Kyoko Hayashi, Kenji Kanekiyo, Yuko Ohta, Jung?Bum Lee, Minoru Hashimoto and Takahisa Nakano
Chapter eight Rational layout of an Anti?Adhesion Drug for Influenza (pages 183–208): Nicolai V. Bovin and Alexandra S. Gambaryan
Chapter nine realizing Influenza Neuraminidase Inhibitors utilizing Quantitative Structure–Activity dating (QSAR) versions (pages 209–225): Rajeshwar P. Verma and Corwin Hansch
Chapter 10 Peptide Inhibitors concentrating on Virus?Cell Fusion at school I Enveloped Viruses (pages 226–246): George F. Gao
Chapter eleven Novel Influenza Therapeutics (pages 247–264): Laura M. Aschenbrenner, Nicole Pelletier, Mang Yu and Fang Fang

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Lancet 2004, 364, 759–765. 50. ; Yates, P. ; McKimm-Breschkin, J. L. Mutations conferring zanamivir resistance in human influenza virus N2 neuraminidases compromise virus fitness and are not stably maintained in vitro. J. Antimicrob. Chemother. 2006, 58, 723–732. 51. Herlocher, M. ; Monto, A. S. Influenza virus carrying an R292K mutation in the neuraminidase gene is not transmitted in ferrets. Antiviral Res. 2002, 54, 99–111. 52. Herlocher, M. ; Roberts, N. ; Ohmit, S. ; Monto, A. S. Influenza viruses resistant to the antiviral drug oseltamivir: transmission studies in ferrets.

Lambkin, R. A new millennium conundrum: How to use a powerful class of influenza anti-neuraminidase drugs (NAIs) in the community. J. Antimicrob. Chemother. 2004, 53, 133–136. 55. Tumpey, T. ; Taubenberger, J. ; Swayne, D. ; Basler, C. F. Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus. Proc. Natl. Acad. Sci. USA 2002, 99, 13849–13854. 56. Ison, M. ; Gubareva, L. ; Atmar, R. ; Hayden, F. G. Recovery of drug-resistant influenza virus from immunocompromised patients: A case series.

Antimicrob. Agents Chemother. 2001, 45, 749–757. ; Kotian, P. ; Lin, T. ; Babu, Y. S. Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo. Bioorg. Med. Chem. 2005, 13, 4071–4077. ; Kotian, P. ; Lin, T. ; Hutchison, T. ; Babu, Y. ; Elliott, A. ; Montgomery, J. A. Systematic structure-based design and stereoselective synthesis of novel multisubsti- 32 71. 72. 73. 74. 75. 76. 77. 78. 79. 80. EXISTING INFLUENZA ANTIVIRALS tuted cyclopentane derivatives with potent antiinfluenza activity.

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